Triptolide

• Supplier: Tocris Bioscience
• Catalog: 0662
• Prices: $115.00, $249.00
• Sizes: 1 mg, 10 mg
• Cas Number: 38748-32-2
• Chemical Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
• Formula: C20H24O6
• Molecular Weight: 360.4
• Purity: >98 %
• Description: Inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC 50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Blocks RNA synthesis in HeLa cells (IC 50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC 50 = 12 nM) and induces apoptosis by blocking TNF- α -mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.

Product References

PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce - PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce

Lee KY, Chang W, Qiu D, Kao PN, Rosen GD. J Biol Chem. 1999 May 7;274(19):13451-5.

Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at - Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at

Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, Ng JC, Kao PN. J Biol Chem. 1999 May 7;274(19):13443-50.

XPB, a subunit of TFIIH, is a target of the natural product triptolide. - XPB, a subunit of TFIIH, is a target of the natural product triptolide.

Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, Goodrich JA, Liu JO. Nat Chem Biol. 2011 Mar;7(3):182-8.