Troglitazone

• Supplier: Tocris Bioscience
• Catalog: 2906
• Prices: $129.00, $519.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 97322-87-7
• Chemical Name: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
• Formula: C24H27NO5S
• Molecular Weight: 441.54
• Purity: >97 %
• Description: Selective PPAR γ receptor agonist (EC 50 values are 780 and 555 nM at murine and human PPAR γ receptors respectively). Displays no activity at PPAR α or PPAR δ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

Product References

Acute effects of troglitazone on in vivo insulin action in normal rats. - Acute effects of troglitazone on in vivo insulin action in normal rats.

Lee MK, Olefsky JM. Metabolism. 1995 Sep;44(9):1166-9.

Effects of troglitazone on the growth and differentiation of hematopoietic cell - Effects of troglitazone on the growth and differentiation of hematopoietic cell

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Ligand type-specific interactions of peroxisome proliferator-activated receptor - Ligand type-specific interactions of peroxisome proliferator-activated receptor

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The PPARs: from orphan receptors to drug discovery. - The PPARs: from orphan receptors to drug discovery.

Willson TM, Brown PJ, Sternbach DD, Henke BR. J Med Chem. 2000 Feb 24;43(4):527-50.