Tropisetron hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0909
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 105826-92-4
• Chemical Name: (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl1H-indole-3-carboxylicacidestermonohydrochloride
• Formula: C17H20N2O2.HCl
• Molecular Weight: 320.82
• Purity: >99 %
• Description: Potent, orally active 5-HT 3 receptor antagonist. Antiemetic. Also partial agonist of α 7 nAChR.

Product References

5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, - 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron,

Seynaeve C, Verweij J, de Mulder PH. Anticancer Drugs. 1991 Aug;2(4):343-55.

Centrally active 5-HT receptor agonists and antagonists. - Centrally active 5-HT receptor agonists and antagonists.

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5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake. - 5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake.

Mhatre M, Pruthi R, Hensley K, Holloway F. Eur J Pharmacol. 2004 May 3;491(2-3):149-56.

Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors - Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors

Papke RL, Porter Papke JK, Rose GM. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1849-53.