Trovafloxacin mesylate

• Supplier: Tocris Bioscience
• Catalog: 2459
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Cas Number: 147059-75-4
• Chemical Name: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylicacidmesylate
• Formula: C20H15F3N4O3.CH3SO3H
• Molecular Weight: 512.46
• Purity: >99 %
• Description: Fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca 2+ . Inhibits Panx-1 (IC 50 ~ 4 μ M).

Product References

In vitro activity of the new fluoroquinolone CP-99,219. - In vitro activity of the new fluoroquinolone CP-99,219.

Neu HC, Chin NX. Antimicrob Agents Chemother. 1994 Nov;38(11):2615-22.

Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase - Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase

Gootz TD, Zaniewski R, Haskell S, Schmieder B, Tankovic J, Girard D, Courvalin P, Polzer RJ. Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7.

Unexpected link between an antibiotic, pannexin channels and apoptosis. - Unexpected link between an antibiotic, pannexin channels and apoptosis.

Poon IK, Chiu YH, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, Ravichandran KS. Nature. 2014 Mar 20;507(7492):329-34.