Tubacin

• Supplier: Tocris Bioscience
• Catalog: 4432
• Prices: $269.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 1350555-93-9
• Chemical Name: N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
• Formula: C41H43N3O7S
• Molecular Weight: 721.86
• Purity: >98 %
• Description: Selective inhibitor of HDAC6; inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α -tubulin deacetylation. Increases α -tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.

Product References

Multidimensional chemical genetic analysis of diversity-oriented - Multidimensional chemical genetic analysis of diversity-oriented

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Domain-selective small-molecule inhibitor of histone deacetylase 6 - Domain-selective small-molecule inhibitor of histone deacetylase 6

Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94. Epub 2003 Apr 3.

Direct binding with histone deacetylase 6 mediates the reversible recruitment of - Direct binding with histone deacetylase 6 mediates the reversible recruitment of

Jiang Q, Ren Y, Feng J. J Neurosci. 2008 Nov 26;28(48):12993-3002.