TW 37

• Supplier: Tocris Bioscience
• Catalog: 3516
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 877877-35-5
• Chemical Name: N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide
• Formula: C33H35NO6S
• Molecular Weight: 573.7
• Purity: >97 %
• Description: Bcl-2 inhibitor (K i values are 0.29 μ M and 1.11 μ M for Bcl-2 and Bcl-XL respectively). Inhibits the angiogenic potential of endothelial cells in vitro . Induces S-phase arrest and apoptosis in pancreatic cancer cell lines; also inhibits the activation of Notch-1 and Jagged-1 in vitro and in vivo .

Product References

Structure-based design of potent small-molecule inhibitors of anti-apoptotic - Structure-based design of potent small-molecule inhibitors of anti-apoptotic

Wang G, Nikolovska-Coleska Z, Yang CY, Wang R, Tang G, Guo J, Shangary S, Qiu S, Gao W, Yang D, Meagher J, Stuckey J, Krajewski K, Jiang S, Roller PP, Abaan HO, Tomita Y, Wang S. J Med Chem. 2006 Oct 19;49(21):6139-42.

Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2. - Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2.

Zeitlin BD, Joo E, Dong Z, Warner K, Wang G, Nikolovska-Coleska Z, Wang S, Nor JE. Cancer Res. 2006 Sep 1;66(17):8698-706.

TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest - TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest

Ashimori N, Zeitlin BD, Zhang Z, Warner K, Turkienicz IM, Spalding AC, Teknos TN, Wang S, Nor JE. Mol Cancer Ther. 2009 Apr;8(4):893-903.

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces - TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces

Wang Z, Azmi AS, Ahmad A, Banerjee S, Wang S, Sarkar FH, Mohammad RM. Cancer Res. 2009 Apr 1;69(7):2757-65.