U 18666A

• Supplier: Tocris Bioscience
• Catalog: 4540
• Prices: $189.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 3039-71-2
• Chemical Name: (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-onehydrochloride
• Formula: C25H41NO2.HCl
• Molecular Weight: 424.07
• Description: Inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo .

Product References

Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in - Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in

Cenedella RJ. Biochem Pharmacol. 1980 Oct 15;29(20):2751-4.

The intracellular transport of low density lipoprotein-derived cholesterol is - The intracellular transport of low density lipoprotein-derived cholesterol is

Liscum L, Faust JR. J Biol Chem. 1989 Jul 15;264(20):11796-806.

Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated - Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated

Incardona JP, Gaffield W, Lange Y, Cooney A, Pentchev PG, Liu S, Watson JA, Kapur RP, Roelink H. Dev Biol. 2000 Aug 15;224(2):440-52.