U 46619

• Supplier: Tocris Bioscience
• Catalog: 1638
• Prices: $139.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 56985-40-1
• Chemical Name: (5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoicacid
• Formula: C21H34O4
• Molecular Weight: 350.5
• Purity: >98 %
• Description: PGH 2 (TXA 2 ) analog that is a potent and stable thromboxane A 2 (TP) receptor agonist (EC 50 = 0.035 μ M). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK 293 cells expressing TP α and TP β receptors.

Product References

Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of - Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of

Coleman RA, Humphrey PP, Kennedy I, Levy GP, Lumley P. Br J Pharmacol. 1981 Jul;73(3):773-8.

Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets. - Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets.

Morinelli TA, Niewiarowski S, Daniel JL, Smith JB. Am J Physiol. 1987 Nov;253(5 Pt 2):H1035-43.

Regulation of extracellular signal-regulated kinase cascades by alpha- and - Regulation of extracellular signal-regulated kinase cascades by alpha- and

Miggin SM, Kinsella BT. Mol Pharmacol. 2002 Apr;61(4):817-31.