| Name | UK 370106 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4187 |
| Prices | $225.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 230961-21-4 |
| Chemical Name | (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoicacid |
| Formula | C35H44N2O5 |
| Molecular Weight | 572.73 |
| Purity | >95 % |
| Description | Highly selective MMP-3 and MMP-12 inhibitor (IC 50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μ M at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC 50 = 320 nM) and has little effect on keratinocyte migration in vitro . Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers. |
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