UK 383367

• Supplier: Tocris Bioscience
• Catalog: 2900
• Prices: $129.00, $279.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 348622-88-8
• Chemical Name: 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
• Formula: C15H24N4O4
• Molecular Weight: 324.38
• Purity: >99 %
• Description: Potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC 50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC 50 values are >10,000 nM for listed MMPs).

Product References

Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for - Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for

Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R. Xenobiotica. 2006 May;36(5):399-418.

Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. - Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.

Fish PV, Allan GA, Bailey S, Blagg J, Butt R, Collis MG, Greiling D, James K, Kendall J, McElroy A, McCleverty D, Reed C, Webster R, Whitlock GA. J Med Chem. 2007 Jul 26;50(15):3442-56. Epub 2007 Jun 26.

Succinyl hydroxamates as potent and selective non-peptidic inhibitors of - Succinyl hydroxamates as potent and selective non-peptidic inhibitors of

Bailey S, Fish PV, Billotte S, Bordner J, Greiling D, James K, McElroy A, Mills JE, Reed C, Webster R. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6562-7.