UK 5099

Name UK 5099
Supplier Tocris Bioscience
Catalog 4188
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 56396-35-1
Chemical Name 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoicacid
Formula C18H12N2O2
Molecular Weight 288.3
Purity >99 %
Description Inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
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Product References

The inhibition of pyruvate transport across the plasma membrane of the - The inhibition of pyruvate transport across the plasma membrane of the

Wiemer EA, Michels PA, Opperdoes FR. Biochem J. 1995 Dec 1;312 ( Pt 2):479-84.

Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. - Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae.

Hildyard JC, Halestrap AP. Biochem J. 2003 Sep 15;374(Pt 3):607-11.

A molecular mechanism of pyruvate protection against cytotoxicity of reactive - A molecular mechanism of pyruvate protection against cytotoxicity of reactive

Hinoi E, Takarada T, Tsuchihashi Y, Fujimori S, Moriguchi N, Wang L, Uno K, Yoneda Y. Mol Pharmacol. 2006 Sep;70(3):925-35. Epub 2006 Jun 9.