UNC 0638

• Supplier: Tocris Bioscience
• Catalog: 3861
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1255517-77-1
• Chemical Name: 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
• Formula: C30H47N5O2
• Molecular Weight: 509.73
• Purity: >99 %
• Description: Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC 50 values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC 50 = 70 nM). Cell permeable.

Product References

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. - Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.

Liu F, Barsyte-Lovejoy D, Allali-Hassani A, He Y, Herold JM, Chen X, Yates CM, Frye SV, Brown PJ, Huang J, Vedadi M, Arrowsmith CH, Jin J. J Med Chem. 2011 Sep 8;54(17):6139-50.

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in - A chemical probe selectively inhibits G9a and GLP methyltransferase activity in

Vedadi M, Barsyte-Lovejoy D, Liu F, Rival-Gervier S, Allali-Hassani A, Labrie V, Wigle TJ, Dimaggio PA, Wasney GA, Siarheyeva A, Dong A, Tempel W, Wang SC, Chen X, Chau I, Mangano TJ, Huang XP, Simpson CD, Pattenden SG, Norris JL, Kireev DB, Tripathy A, Edwards A, Roth BL, Janzen WP, Garcia BA, Petronis A, Ellis J, Brown PJ, Frye SV, Arrowsmith CH, Jin J. Nat Chem Biol. 2011 Jul 10;7(8):566-74.