UNC 0642

• Supplier: Tocris Bioscience
• Catalog: 4343
• Prices: $245.00, $1,005.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1481677-78-4
• Chemical Name: 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
• Formula: C29H44F2N6O2
• Molecular Weight: 546.7
• Purity: >99 %
• Description: Potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC 50 < 2.5 nM). Exhibits >2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and >20,000-fold selectivity over other methyltransferases. Reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC 50 = 110 nM). Displays modest brain penetration in vivo .

Product References

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and - Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and

Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. J Med Chem. 2013 Nov 14;56(21):8931-42.