| Name | UNC 0646 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5132 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1320288-17-2 |
| Chemical Name | N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine |
| Formula | C36H59N7O2 |
| Molecular Weight | 621.9 |
| Purity | >99 % |
| Description | Potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC 50 values are 6 nM and 15 nM for G9a and GLP, respectively). Potently blocks G9a/GLP methyltransferase activity in cells (IC 50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC 50 = 4.7 μ M in MCF7 cells). Selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases. |
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