| Name | UNC 1999 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4666 |
| Prices | $195.00, $805.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1431612-23-5 |
| Chemical Name | N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide |
| Formula | C33H43N7O2 |
| Molecular Weight | 569.74 |
| Purity | >99 % |
| Description | Potent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC 50 values are 2 and 45 nM respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro . Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable. |
| Supplier Page | Shop |
Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J. ACS Chem Biol. 2013;8(6):1324-34.
Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG. Blood. 2015 Jan 8;125(2):346-57.