UNC 2400

Name	UNC 2400
Supplier	Tocris Bioscience
Catalog	5057
Prices	$195.00
Sizes	10 mg
Cas Number	1433200-49-7
Chemical Name	N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide
Formula	C35H47N7O2
Molecular Weight	597.79
Purity	>98 %
Description	Negative control of UNC 1999 (Cat. No. 4904). Exhibits 1000-fold lower potency than active analog (IC 50 values are 62 and >200 μ M for EZH1 and EZH2, respectively).
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Product References

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and - An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and

Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J. ACS Chem Biol. 2013;8(6):1324-34.

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule - Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule

Xu B, On DM, Ma A, Parton T, Konze KD, Pattenden SG, Allison DF, Cai L, Rockowitz S, Liu S, Liu Y, Li F, Vedadi M, Frye SV, Garcia BA, Zheng D, Jin J, Wang GG. Blood. 2015 Jan 8;125(2):346-57.