UPF 648

• Supplier: Tocris Bioscience
• Catalog: 3736
• Prices: $289.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 213400-34-1
• Chemical Name: (1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylicacid
• Formula: C11H8Cl2O3
• Molecular Weight: 259.09
• Purity: >98 %
• Description: Potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (IC 50 = 20 nM). Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease.

Product References

Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological - Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological

Ceresoli-Borroni G, Guidetti P, Amori L, Pellicciari R, Schwarcz R. J Neurosci Res. 2007 Mar;85(4):845-54.

On the relationship between the two branches of the kynurenine pathway in the rat - On the relationship between the two branches of the kynurenine pathway in the rat

Amori L, Guidetti P, Pellicciari R, Kajii Y, Schwarcz R. J Neurochem. 2009 Apr;109(2):316-25.

The kynurenine pathway modulates neurodegeneration in a Drosophila model of - The kynurenine pathway modulates neurodegeneration in a Drosophila model of

Campesan S, Green EW, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. Curr Biol. 2011 Jun 7;21(11):961-6.

Structural basis of kynurenine 3-monooxygenase inhibition. - Structural basis of kynurenine 3-monooxygenase inhibition.

Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS. Nature. 2013 Apr 18;496(7445):382-5.