Urantide

• Supplier: Tocris Bioscience
• Catalog: 4926
• Prices: $185.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 669089-53-6
• Formula: C51H66N10O12S2
• Molecular Weight: 1075.26
• Description: Selective and competitive urotensin-II (UT) receptor antagonist (pK B = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo . Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).

Product References

Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. - Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta.

Patacchini R, Santicioli P, Giuliani S, Grieco P, Novellino E, Rovero P, Maggi CA. Br J Pharmacol. 2003 Dec;140(7):1155-8.

Lead optimization of P5U and urantide: discovery of novel potent ligands at the - Lead optimization of P5U and urantide: discovery of novel potent ligands at the

Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P. J Med Chem. 2014 Jul 24;57(14):5965-74.