URB 597

• Supplier: Tocris Bioscience
• Catalog: 1772
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 546141-08-6
• Chemical Name: Cyclohexylcarbamicacid3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-ylester
• Formula: C20H22N2O3
• Molecular Weight: 338.4
• Purity: >99 %
• Description: Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC 50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

Product References

An endocannabinoid mechanism for stress-induced analgesia. - An endocannabinoid mechanism for stress-induced analgesia.

Hohmann AG, Suplita RL, Bolton NM, Neely MH, Fegley D, Mangieri R, Krey JF, Walker JM, Holmes PV, Crystal JD, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. Nature. 2005 Jun 23;435(7045):1108-12.

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain - Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain

Jayamanne A, Greenwood R, Mitchell VA, Aslan S, Piomelli D, Vaughan CW. Br J Pharmacol. 2006 Feb;147(3):281-8.

Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). - Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR, Dasse O, Monaghan EP, Parrott JA, Putman D. CNS Drug Rev. 2006 Spring;12(1):21-38.