Valerenic acid

• Supplier: Tocris Bioscience
• Catalog: 4206
• Prices: $129.00
• Sizes: 1 mg
• Function Type: Modulator
• Cas Number: 3569-10-6
• Chemical Name: (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoicacid
• Formula: C15H22O2
• Molecular Weight: 234.33
• Purity: >99 %
• Description: Positive allosteric modulator of GABA A receptors that displays preference for receptors containing β 2 or β 3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo . Also acts as a partial agonist of 5-HT 5A receptors.

Product References

Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor - Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor

Dietz BM, Mahady GB, Pauli GF, Farnsworth NR. Brain Res Mol Brain Res. 2005 Aug 18;138(2):191-7.

GABA A receptors as in vivo substrate for the anxiolytic action of valerenic - GABA A receptors as in vivo substrate for the anxiolytic action of valerenic

Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Mohler H. Neuropharmacology. 2009 Jan;56(1):174-81.