Valsartan

• Supplier: Tocris Bioscience
• Catalog: 2815
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 137862-53-4
• Chemical Name: (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoicacid
• Formula: C24H29N5O3
• Molecular Weight: 435.52
• Purity: >99 %
• Description: High affinity AT 1 receptor antagonist (K i = 2.38 nM). Displays 30,000-fold selectivity over AT 2 receptors. Inhibits angiotensin II-induced release of aldosterone in vitro . Orally active.

Product References

Pharmacological profile of valsartan: a potent, orally active, nonpeptide - Pharmacological profile of valsartan: a potent, orally active, nonpeptide

Criscione L, de Gasparo M, Buhlmayer P, Whitebread S, Ramjoue HP, Wood J. Br J Pharmacol. 1993 Oct;110(2):761-71.

Nonpeptide angiotensin II receptor antagonists: the next generation in - Nonpeptide angiotensin II receptor antagonists: the next generation in

Wexler RR, Greenlee WJ, Irvin JD, Goldberg MR, Prendergast K, Smith RD, Timmermans PB. J Med Chem. 1996 Feb 2;39(3):625-56.

Effects of angiotensin II blockade on inflammation-induced alterations of - Effects of angiotensin II blockade on inflammation-induced alterations of

Hanafy S, Dagenais NJ, Dryden WF, Jamali F. Br J Pharmacol. 2008 Jan;153(1):90-9. Epub 2007 Oct 29.