Varenicline tartrate

• Supplier: Tocris Bioscience
• Catalog: 2181
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 375815-87-5
• Chemical Name: 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepinetartrate
• Formula: C13H13N3.C4H6O6
• Molecular Weight: 361.37
• Purity: >99 %
• Description: Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo .

Product References

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking - Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking

Coe JW, Brooks PR, Vetelino MG, Wirtz MC, Arnold EP, Huang J, Sands SB, Davis TI, Lebel LA, Fox CB, Shrikhande A, Heym JH, Schaeffer E, Rollema H, Lu Y, Mansbach RS, Chambers LK, Rovetti CC, Schulz DW, Tingley FD 3rd, O'Neill BT. J Med Chem. 2005 May 19;48(10):3474-7.

Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor - Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor

Rollema H, Chambers LK, Coe JW, Glowa J, Hurst RS, Lebel LA, Lu Y, Mansbach RS, Mather RJ, Rovetti CC, Sands SB, Schaeffer E, Schulz DW, Tingley FD 3rd, Williams KE. Neuropharmacology. 2007 Mar;52(3):985-94. Epub 2006 Dec 8.

Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline - Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline

Rollema H, Hajos M, Seymour PA, Kozak R, Majchrzak MJ, Guanowsky V, Horner WE, Chapin DS, Hoffmann WE, Johnson DE, McLean S, Freeman J, Williams KE. Biochem Pharmacol. 2009 Oct 1;78(7):813-24.