Venlafaxine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1686
• Prices: $115.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 99300-78-4
• Chemical Name: 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanolhydrochloride
• Formula: C17H27NO2.HCl
• Molecular Weight: 313.86
• Purity: >99 %
• Description: Dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (K i values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

Product References

Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim - Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim

Gamen S, Anel A, Perez-Galan P, Lasierra P, Johnson D, Pineiro A, Naval J. Exp Cell Res. 2000 Jul 10;258(1):223-35.

Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial - Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial

Meguro T, Chen B, Parent AD, Zhang JH. Stroke. 2001 Feb;32(2):561-6.

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during - Caspase-2 acts upstream of mitochondria to promote cytochrome c release during

Robertson JD, Enoksson M, Suomela M, Zhivotovsky B, Orrenius S. J Biol Chem. 2002 Aug 16;277(33):29803-9. Epub 2002 Jun 13.