VER 155008

• Supplier: Tocris Bioscience
• Catalog: 2917
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1134156-31-2
• Chemical Name: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
• Formula: C25H23Cl2N7O4
• Molecular Weight: 556.4
• Purity: >98 %
• Description: Novel adenosine-derived inhibitor of Heat Shock Protein 70 (Hsp70) (IC 50 = 0.5 μ M). Inhibits cell proliferation of multiple human tumor cell lines in vitro . Also binds Hsc70 and Grp78; displays selectivity against Hsp90 β (IC 50 >200 μ M for Hsp90 β ).

Product References

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor - A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor

Massey AJ, Williamson DS, Browne H, Murray JB, Dokurno P, Shaw T, Macias AT, Daniels Z, Geoffroy S, Dopson M, Lavan P, Matassova N, Francis GL, Graham CJ, Parsons R, Wang Y, Padfield A, Comer M, Drysdale MJ, Wood M. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45. doi:

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered - Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered

Williamson DS, Borgognoni J, Clay A, Daniels Z, Dokurno P, Drysdale MJ, Foloppe N, Francis GL, Graham CJ, Howes R, Macias AT, Murray JB, Parsons R, Shaw T, Surgenor AE, Terry L, Wang Y, Wood M, Massey AJ. J Med Chem. 2009 Mar 26;52(6):1510-3.

ATPases as drug targets: insights from heat shock proteins 70 and 90. - ATPases as drug targets: insights from heat shock proteins 70 and 90.

Massey AJ. J Med Chem. 2010 Oct 28;53(20):7280-6.