Verteporfin

Name	Verteporfin
Supplier	Tocris Bioscience
Catalog	2918
Prices	$169.00
Sizes	10 mg
Function Type	Inhibitor
Cas Number	129497-78-5
Chemical Name	(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoicacidmonomethylester
Formula	C41H42N4O8
Molecular Weight	718.79
Purity	>97 %
Description	YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC 50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro . Suppresses YAP-induced liver overgrowth in mice.
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Product References

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the - Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the

Liu-Chittenden Y, Huang B, Shim JS, Chen Q, Lee SJ, Anders RA, Liu JO, Pan D. Genes Dev. 2012 Jun 15;26(12):1300-5.

The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human - The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human

Brodowska K, Al-Moujahed A, Marmalidou A, Meyer Zu Horste M, Cichy J, Miller JW, Gragoudas E, Vavvas DG. Exp Eye Res. 2014 Jul;124:67-73.

Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with - Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with

Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, Hung MC, Johnson RL. Cancer Res. 2014 Aug 1;74(15):4170-82.