Vialinin A

• Supplier: Tocris Bioscience
• Catalog: 0653
• Prices: $79.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 858134-23-3
• Chemical Name: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl)benzeneaceticacidester
• Formula: C34H26O8
• Molecular Weight: 562.57
• Purity: >98 %
• Description: Inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC 50 values are 1.5, 5.9 and 22.3 μ M, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF- α (IC 50 = 0.09 nM) from RBL-2H3 mast cells. Displays anti-cancer activity decreasing viability in human colonic carcinoma cells.

Product References

Anticancer activities of thelephantin O and vialinin A isolated from Thelephora - Anticancer activities of thelephantin O and vialinin A isolated from Thelephora

Norikura T, Fujiwara K, Narita T, Yamaguchi S, Morinaga Y, Iwai K, Matsue H. J Agric Food Chem. 2011 Jul 13;59(13):6974-9.

Inhibitory effects of vialinin A and its analog on tumor necrosis factor-alpha - Inhibitory effects of vialinin A and its analog on tumor necrosis factor-alpha

Onose J, Yoshioka Y, Ye YQ, Sugaya K, Yajima A, Taniguchi K, Okada K, Yajima S, Takahashi S, Koshino H, Abe N. Cell Immunol. 2012 Oct;279(2):140-4.

Vialinin A is a ubiquitin-specific peptidase inhibitor. - Vialinin A is a ubiquitin-specific peptidase inhibitor.

Okada K, Ye YQ, Taniguchi K, Yoshida A, Akiyama T, Yoshioka Y, Onose J, Koshino H, Takahashi S, Yajima A, Abe N, Yajima S. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4328-31.