Vinorelbine ditartrate

• Supplier: Tocris Bioscience
• Catalog: 1257
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 125317-39-7
• Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylicacidmethylester
• Formula: C45H54N4O8.2C4H6O6
• Molecular Weight: 1079.1
• Purity: >97 %
• Description: Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC 50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC 50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Product References

Vinorelbine (Navelbine): a third-generation vinca alkaloid. - Vinorelbine (Navelbine): a third-generation vinca alkaloid.

Budman DR. Cancer Invest. 1997;15(5):475-90.

Mechanism of mitotic block and inhibition of cell proliferation by the - Mechanism of mitotic block and inhibition of cell proliferation by the

Ngan VK, Bellman K, Hill BT, Wilson L, Jordan MA. Mol Pharmacol. 2001 Jul;60(1):225-32.

The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. - The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics.

Okouneva T, Hill BT, Wilson L, Jordan MA. Mol Cancer Ther. 2003 May;2(5):427-36.