| Name | VO-OHpic |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3596 |
| Prices | $139.00, $585.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 675848-25-6 |
| Chemical Name | (OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen |
| Formula | C12H10N2O8V |
| Molecular Weight | 361.16 |
| Purity | >98 % |
| Description | Potent inhibitor of PTEN (phosphatase and tensin homolog) (IC 50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTP β and SAC (IC 50 values are 588 nM, 4.03, 57.5 and >10 μ M respectively). Increases PIP 2 and PIP 3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated T regs . Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice. |
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