VU 0155069

Name VU 0155069
Supplier Tocris Bioscience
Catalog 3311
Prices $205.00, $845.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1130067-06-9
Chemical Name N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
Formula C26H27ClN4O2.HCl
Molecular Weight 499.43
Purity >98 %
Description Potent and selective phospholipase D1 (PLD1) inhibitor (IC 50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.
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Product References

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part - Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part

Lewis JA, Scott SA, Lavieri R, Buck JR, Selvy PE, Stoops SL, Armstrong MD, Brown HA, Lindsley CW. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20.

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell - Design of isoform-selective phospholipase D inhibitors that modulate cancer cell

Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA. Nat Chem Biol. 2009 Feb;5(2):108-17.