VU 0240551

• Supplier: Tocris Bioscience
• Catalog: 3634
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 893990-34-6
• Chemical Name: N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
• Formula: C16H14N4OS2
• Molecular Weight: 342.43
• Purity: >99 %
• Description: Inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC 50 = 560 nM for K + uptake assay in KCC2-overexpressing cells). Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca 2+ channels.

Product References

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter - Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter

Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. doi:

Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development - Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development

Delpire E, Baranczak A, Waterson AG, Kim K, Kett N, Morrison RD, Daniels JS, Weaver CD, Lindsley CW. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.

Effects of VU0240551, a novel KCC2 antagonist, and DIDS on chloride homeostasis - Effects of VU0240551, a novel KCC2 antagonist, and DIDS on chloride homeostasis

Deisz RA, Wierschke S, Schneider UC, Dehnicke C. Neuroscience. 2014 Sep 26;277:831-41.