| Name | VU 0285683 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3727 |
| Prices | $175.00, $709.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Modulator |
| Cas Number | 327056-22-4 |
| Chemical Name | 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile |
| Formula | C14H7FN4O |
| Molecular Weight | 266.23 |
| Purity | >98 % |
| Description | Negative allosteric modulator of mGlu 5 receptors. Displays high affinity for the MPEP (Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu 5 (IC 50 = 24.4 nM). Selective for mGlu 5 over mGlu 1 , mGlu 3 and mGlu 4 . Exhibits anxiolytic activity in rodent models of anxiety. Analog available (Cat. No. 4323). |
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