Name | VU 0361737 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 4394 |
Prices | $129.00, $535.00 |
Sizes | 10 mg, 50 mg |
Function Type | Modulator |
Cas Number | 1161205-04-4 |
Chemical Name | N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide |
Formula | C13H11ClN2O2 |
Molecular Weight | 262.69 |
Purity | >99 % |
Description | Selective positive allosteric modulator at mGlu 4 receptors (EC 50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu 1 , mGlu 2 , mGlu 3 , mGlu 6 and mGlu 7 receptors and displays weak activity at mGlu 5 and mGlu 8 receptors. Brain penetrant. |
Supplier Page | Shop |
Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, Hopkins CR. J Med Chem. 2009 Jul 23;52(14):4115-8.
Engers DW, Field JR, Le U, Zhou Y, Bolinger JD, Zamorano R, Blobaum AL, Jones CK, Jadhav S, Weaver CD, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR. J Med Chem. 2011 Feb 24;54(4):1106-10.