VU 0365114

• Supplier: Tocris Bioscience
• Catalog: 4469
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 1208222-39-2
• Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
• Formula: C22H14F3NO3
• Molecular Weight: 397.35
• Purity: >98 %
• Description: Selective positive allosteric modulator of M 5 (EC 50 values are 2.7 μ M for human M 5 , and >30 μ M for M 1 , M 2 , M 3 and M 4 receptors).

Product References

Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive - Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive

Bridges TM, Kennedy JP, Cho HP, Breininger ML, Gentry PR, Hopkins CR, Conn PJ, Lindsley CW. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62.

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. - Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.

Bridges TM, Kennedy JP, Hopkins CR, Conn PJ, Lindsley CW. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22.