| Name | VU 0463271 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5378 |
| Prices | $165.00, $685.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1391737-01-1 |
| Chemical Name | N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide |
| Formula | C19H18N4OS2 |
| Molecular Weight | 382.5 |
| Purity | >98 % |
| Description | Potent and selective inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC 50 = 61 nM); displays >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters. |
| Supplier Page | Shop |
Delpire E, Baranczak A, Waterson AG, Kim K, Kett N, Morrison RD, Daniels JS, Weaver CD, Lindsley CW. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.
Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ. J Neurosci. 2015 May 27;35(21):8291-6.