VU 29

• Supplier: Tocris Bioscience
• Catalog: 3325
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Cas Number: 890764-36-0
• Chemical Name: N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide
• Formula: C22H16N4O3
• Molecular Weight: 384.39
• Purity: >99 %
• Description: Potent allosteric potentiator at the rat mGlu 5 receptor (EC 50 = 9 nM); binds to the MPEP (Cat. No. 1212) allosteric site (K i app = 244 nM). Selective for mGlu5 over mGlu 1 and mGlu 2 receptors (EC 50 values are 557 nM and 1.51 μ M for mGlu 1 and mGlu 2 respectively). Potentiates both DHPG-induced LTP and threshold θ -burst stimulation (TBS)-induced LTP in rat hippocampal slices. Analog of CDPPB (Cat. No. 3235).

Product References

Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive - Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive

de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ. J Med Chem. 2006 Jun 1;49(11):3332-44.

Interaction of novel positive allosteric modulators of metabotropic glutamate - Interaction of novel positive allosteric modulators of metabotropic glutamate

Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ. Mol Pharmacol. 2007 May;71(5):1389-98. Epub 2007 Feb 15.

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and - mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and

Ayala JE, Chen Y, Banko JL, Sheffler DJ, Williams R, Telk AN, Watson NL, Xiang Z, Zhang Y, Jones PJ, Lindsley CW, Olive MF, Conn PJ. Neuropsychopharmacology. 2009 Aug;34(9):2057-71.