| Name | VUF 10166 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4197 |
| Prices | $159.00, $665.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 155584-74-0 |
| Chemical Name | 2-Chloro-3-(4-methyl-1-piperazinyl)quinoxaline |
| Formula | C13H15ClN4 |
| Molecular Weight | 262.74 |
| Purity | >98 % |
| Description | High affinity 5-HT 3 receptor antagonist (IC 50 values are 0.04 and 22 nM for human 5HT 3A and 5-HT 3AB receptors respectively). Exhibits partial agonist activity at 5-HT 3A receptors at higher concentrations (EC 50 = 5.2 μ M). Also histamine H 4 receptor antagonist (pK i = 6.64 in HEK cells). |
| Supplier Page | Shop |
Smits RA, Lim HD, Hanzer A, Zuiderveld OP, Guaita E, Adami M, Coruzzi G, Leurs R, de Esch IJ. J Med Chem. 2008 Apr 24;51(8):2457-67.
Thompson AJ, Verheij MH, de Esch IJ, Lummis SC. J Pharmacol Exp Ther. 2012 May;341(2):350-9.