VUF 8430 dihydrobromide

Name VUF 8430 dihydrobromide
Supplier Tocris Bioscience
Catalog 2493
Prices $139.00, $585.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 100130-32-3
Chemical Name 2-[(Aminoiminomethyl)amino]ethylcarbamimidothioicacidesterdihydrobromide
Formula C4H11N5S.2HBr
Molecular Weight 323.05
Description High affinity (pK i = 7.5), potent histamine H 4 receptor full agonist (pEC 50 = 7.3). Displays moderate affinity for H 3 receptors (pK i = 6.0) and weak partial agonist activity at H 2 receptors.
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Product References

The influence of guanidino and isothiourea groups in histaminergic compounds on - The influence of guanidino and isothiourea groups in histaminergic compounds on

Sterk GJ, van der Goot H, Timmerman H. Agents Actions. 1986 Apr;18(1-2):137-40.

Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole - Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole

Lim HD, Smits RA, Bakker RA, van Dam CM, de Esch IJ, Leurs R. J Med Chem. 2006 Nov 16;49(23):6650-1.

Phenylalanine 169 in the second extracellular loop of the human histamine H4 - Phenylalanine 169 in the second extracellular loop of the human histamine H4

Lim HD, Jongejan A, Bakker RA, Haaksma E, de Esch IJ, Leurs R. J Pharmacol Exp Ther. 2008 Oct;327(1):88-96.