VX 745

• Supplier: Tocris Bioscience
• Catalog: 3916
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 209410-46-8
• Chemical Name: 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one
• Formula: C19H9Cl2F2N3OS
• Molecular Weight: 436.26
• Purity: >98 %
• Description: Highly potent and selective p38 α inhibitor (IC 50 = 10 nM). Also blocks TNF α production in LPS-stimulated HWB in vitro (IC 50 = 177 nM). Displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and JNK1-3.

Product References

Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. - Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells.

Bagley MC, Davis T, Dix MC, Rokicki MJ, Kipling D. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5107-10. Epub 2007 Jul 13.

Selective p38alpha inhibitors clinically evaluated for the treatment of chronic - Selective p38alpha inhibitors clinically evaluated for the treatment of chronic

Goldstein DM, Kuglstatter A, Lou Y, Soth MJ. J Med Chem. 2010 Mar 25;53(6):2345-53.