W-13 hydrochloride

Name W-13 hydrochloride
Supplier Tocris Bioscience
Catalog 1415
Prices $139.00, $585.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 88519-57-7
Chemical Name N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamidehydrochloride
Formula C14H17ClN2O2S.HCl
Molecular Weight 349.27
Purity >98 %
Description Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells.
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Product References

Naphthalenesulfonamides as calmodulin antagonists. - Naphthalenesulfonamides as calmodulin antagonists.

Hidaka H, Tanaka T. Methods Enzymol. 1983;102:185-94.

Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, - Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine,

Strobl JS, Peterson VA. J Pharmacol Exp Ther. 1992 Oct;263(1):186-93.

Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of - Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of

Bosch M, Gil J, Bachs O, Agell N. J Biol Chem. 1998 Aug 21;273(34):22145-50.