W146

• Supplier: Tocris Bioscience
• Catalog: 0361
• Prices: $155.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 909725-61-7
• Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonicacid
• Formula: C16H27N2O4P
• Molecular Weight: 342.37
• Purity: >98 %
• Description: Potent sphingosine-1-phosphate receptor S1P 1 selective antagonist (K i = 18 nM); displays no effect at S1P 2 , S1P 3 or S1P 5 . Enhances capillary leakage and restores lymphocyte egress in vivo .

Product References

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral - Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral

Sanna MG, Wang SK, Gonzalez-Cabrera PJ, Don A, Marsolais D, Matheu MP, Wei SH, Parker I, Jo E, Cheng WC, Cahalan MD, Wong CH, Rosen H. Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9.

Full pharmacological efficacy of a novel S1P1 agonist that does not require - Full pharmacological efficacy of a novel S1P1 agonist that does not require

Gonzalez-Cabrera PJ, Jo E, Sanna MG, Brown S, Leaf N, Marsolais D, Schaeffer MT, Chapman J, Cameron M, Guerrero M, Roberts E, Rosen H. Mol Pharmacol. 2008 Nov;74(5):1308-18.