W-7 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0368
• Prices: $129.00
• Sizes: 100 mg
• Function Type: Antagonist
• Cas Number: 61714-27-0
• Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamidehydrochloride
• Formula: C16H21ClN2O2S.HCl
• Molecular Weight: 377.33
• Purity: >98 %
• Description: Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

Product References

Hydrophobic regions function in calmodulin-enzyme(s) interactions. - Hydrophobic regions function in calmodulin-enzyme(s) interactions.

Tanaka T, Hidaka H. J Biol Chem. 1980 Dec 10;255(23):11078-80.

N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, - N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist,

Hidaka H, Sasaki Y, Tanaka T, Endo T, Ohno S, Fujii Y, Nagata T. Proc Natl Acad Sci U S A. 1981 Jul;78(7):4354-7.

Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent - Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent

Itoh H, Hidaka H. J Biochem. 1984 Dec;96(6):1721-6.

Divergent pharmacological effects of three calmodulin antagonists, - Divergent pharmacological effects of three calmodulin antagonists,

Asano M. J Pharmacol Exp Ther. 1989 Nov;251(2):764-73.