W-84 dibromide

Name W-84 dibromide
Supplier Tocris Bioscience
Catalog 0369
Prices $139.00, $585.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 21093-51-6
Chemical Name Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
Formula C32H44Br2N4O4
Molecular Weight 708.53
Description Stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Increases the protective effect of atropine against organophosphate poisoning.
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Product References

Antimuscarinic action of an alkane-bis-ammonium compound alone and in combination - Antimuscarinic action of an alkane-bis-ammonium compound alone and in combination

Mitchelson F. Eur J Pharmacol. 1975 Sep-Oct;33(2):237-46.

Allosteric stabilization of 3H-N-methylscopolamine binding in guinea-pig - Allosteric stabilization of 3H-N-methylscopolamine binding in guinea-pig

Jepsen K, Lullmann H, Mohr K, Pfeffer J. Pharmacol Toxicol. 1988 Sep;63(3):163-8.

Equipotent allosteric effect of W84 on [3H]NMS-binding to cardiac muscarinic - Equipotent allosteric effect of W84 on [3H]NMS-binding to cardiac muscarinic

Mohr K, Staschen CM, Ziegenhagen M. Pharmacol Toxicol. 1992 Mar;70(3):198-200.