WAY 100635 maleate

Name WAY 100635 maleate
Supplier Tocris Bioscience
Catalog 1253
Prices $165.00, $685.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 634908-75-1
Chemical Name N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamidemaleate
Formula C25H34N4O2.C4H4O4
Molecular Weight 538.64
Purity >99 %
Description Potent, silent antagonist of 5-HT 1A receptors (IC 50 = 2.2 nM; K i = 0.84 nM for rat 5-HT 1A receptors). Displays 100-fold selectivity for 5-HT 1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D 4 receptors.
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Product References

Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- - Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-

Zhuang ZP, Kung MP, Kung HF. J Med Chem. 1994 May 13;37(10):1406-7.

A pharmacological profile of the selective silent 5-HT1A receptor antagonist, - A pharmacological profile of the selective silent 5-HT1A receptor antagonist,

Forster EA, Cliffe IA, Bill DJ, Dover GM, Jones D, Reilly Y, Fletcher A. Eur J Pharmacol. 1995 Jul 25;281(1):81-8.

Synthesis and in vitro and in vivo functional studies of ortho-substituted - Synthesis and in vitro and in vivo functional studies of ortho-substituted

Mensonides-Harsema MM, Liao Y, Bottcher H, Bartoszyk GD, Greiner HE, Harting J, de Boer P, Wikstrom HV. J Med Chem. 2000 Feb 10;43(3):432-9.

WAY-100635 is a potent dopamine D4 receptor agonist. - WAY-100635 is a potent dopamine D4 receptor agonist.

Chemel BR, Roth BL, Armbruster B, Watts VJ, Nichols DE. Psychopharmacology (Berl). 2006 Oct;188(2):244-51. Epub 2006 Aug 17.