| Name | WAY 252623 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2652 |
| Prices | $149.00, $629.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 875787-07-8 |
| Chemical Name | 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole |
| Formula | C21H12ClF5N2 |
| Molecular Weight | 422.78 |
| Purity | >98 % |
| Description | Potent LXR agonist (IC 50 values are 24 and 179 nM for LXR β and LXR α , respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable. |
| Supplier Page | Shop |
Bodine PV, Stauffer B, Ponce-de-Leon H, Bhat RA, Mangine A, Seestaller-Wehr LM, Moran RA, Billiard J, Fukayama S, Komm BS, Pitts K, Krishnamurthy G, Gopalsamy A, Shi M, Kern JC, Commons TJ, Woodworth RP, Wilson MA, Welmaker GS, Trybulski EJ, Moore WJ. Bone. 2009 Jun;44(6):1063-8.
Moore WJ, Kern JC, Bhat R, Commons TJ, Fukayama S, Goljer I, Krishnamurthy G, Magolda RL, Nogle L, Pitts K, Stauffer B, Trybulski EJ, Welmaker GS, Wilson M, Bodine PV. J Med Chem. 2009 Jan 8;52(1):105-16.
Moore WJ, Kern JC, Bhat R, Bodine PV, Fukyama S, Krishnamurthy G, Magolda RL, Pitts K, Stauffer B, Trybulski EJ. Bioorg Med Chem. 2010 Jan 1;18(1):190-201.