WEB 2086

• Supplier: Tocris Bioscience
• Catalog: 5323
• Prices: $115.00, $249.00
• Sizes: 1 mg, 10 mg
• Function Type: Antagonist
• Cas Number: 105219-56-5
• Chemical Name: 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
• Formula: C22H22N5O2SCl
• Molecular Weight: 455.96
• Purity: >99 %
• Description: Potent, selective platelet-activating factor (PAF) receptor antagonist (K i = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.

Product References

Characterization of PAF receptors on human neutrophils using the specific - Characterization of PAF receptors on human neutrophils using the specific

Dent G, Ukena D, Chanez P, Sybrecht G, Barnes P. FEBS Lett. 1989 Feb 27;244(2):365-8.

Effects of WEB 2086 on the protective role of preconditioning against arrhythmias - Effects of WEB 2086 on the protective role of preconditioning against arrhythmias

Sariahmetoglu M, Cakici I, Kanzik I. Pharmacol Res. 1998 Sep;38(3):173-8.

Growth inhibition and differentiation of human breast cancer cells by the PAFR - Growth inhibition and differentiation of human breast cancer cells by the PAFR

Cellai C, Laurenzana A, Vannucchi AM, Caporale R, Paglierani M, Di Lollo S, Pancrazzi A, Paoletti F. Br J Cancer. 2006 Jun 5;94(11):1637-42.