WHI-P 154

• Supplier: Tocris Bioscience
• Catalog: 5413
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 211555-04-3
• Chemical Name: 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
• Formula: C16H14BrN3O3
• Molecular Weight: 376.2
• Purity: >99 %
• Description: JAK3 inhibitor (IC 50 = 1.8 μ M) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro . Also inhibits other common kinases including EGFR (IC 50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC 50 = 158 μ M). Induces differentiation of neural progenitor cells.

Product References

4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline - 4-(3'-Bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline

Narla RK, Liu XP, Myers DE, Uckun FM. Clin Cancer Res. 1998 Jun;4(6):1405-14.

The specificity of JAK3 kinase inhibitors. - The specificity of JAK3 kinase inhibitors.

Changelian PS, Moshinsky D, Kuhn CF, Flanagan ME, Munchhof MJ, Harris TM, Whipple DA, Doty JL, Sun J, Kent CR, Magnuson KS, Perregaux DG, Sawyer PS, Kudlacz EM. Blood. 2008 Feb 15;111(4):2155-7. Epub 2007 Dec 19.

Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial - Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial

Sareila O, Korhonen R, Karpanniemi O, Nieminen R, Kankaanranta H, Moilanen E. Int Immunopharmacol. 2008 Jan;8(1):100-8. Epub 2007 Nov 20.

Differential regulation of proliferation and differentiation in neural precursor - Differential regulation of proliferation and differentiation in neural precursor

Kim YH, Chung JI, Woo HG, Jung YS, Lee SH, Moon CH, Suh-Kim H, Baik EJ. Stem Cells. 2010 Oct;28(10):1816-28.