WIN 18446

• Supplier: Tocris Bioscience
• Catalog: 4855
• Prices: $109.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 1477-57-2
• Chemical Name: N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
• Formula: C12H20Cl4N2O2
• Molecular Weight: 366.11
• Description: Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC 50 = 0.3 μ M). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.

Product References

Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by - Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by

Amory JK, Muller CH, Shimshoni JA, Isoherranen N, Paik J, Moreb JS, Amory DW Sr, Evanoff R, Goldstein AS, Griswold MD. J Androl. 2011 Jan-Feb;32(1):111-9.

Suppression of Stra8 expression in the mouse gonad by WIN 18,446. - Suppression of Stra8 expression in the mouse gonad by WIN 18,446.

Hogarth CA, Evanoff R, Snyder E, Kent T, Mitchell D, Small C, Amory JK, Griswold MD. Biol Reprod. 2011 May;84(5):957-65.