WIN 64338 hydrochloride

Name WIN 64338 hydrochloride
Supplier Tocris Bioscience
Catalog 2327
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 163727-74-0
Chemical Name (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyltributylphosphoniumchloridehydrochloride
Formula C45H68ClN4OP.HCl
Molecular Weight 783.95
Description The first potent, non-peptide, competitive bradykinin B 2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [ 3 H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B 1 preparation).
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Product References

Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the - Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the

Marceau F, Levesque L, Drapeau G, Rioux F, Salvino JM, Wolfe HR, Seoane PR, Sawutz DG. J Pharmacol Exp Ther. 1994 Jun;269(3):1136-43.

Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on - Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on

Scherrer D, Daeffler L, Trifilieff A, Gies JP. Br J Pharmacol. 1995 Aug;115(7):1127-8.

Action of bradykinin in the submucosal plexus of guinea pig small intestine. - Action of bradykinin in the submucosal plexus of guinea pig small intestine.

Hu HZ, Gao N, Liu S, Ren J, Wang X, Xia Y, Wood JD. J Pharmacol Exp Ther. 2004 Apr;309(1):320-7. Epub 2004 Jan 12.