Wiskostatin

Name Wiskostatin
Supplier Tocris Bioscience
Catalog 1057
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 253449-04-6
Chemical Name 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
Formula C17H18Br2N2O
Molecular Weight 426.15
Purity >99 %
Description Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP 2 -induced actin polymerization (EC 50 ~ 4 μ M).
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Product References

Chemical inhibition of N-WASP by stabilization of a native autoinhibited - Chemical inhibition of N-WASP by stabilization of a native autoinhibited

Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK. Nat Struct Mol Biol. 2004 Aug;11(8):747-55. Epub 2004 Jul 4.

N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by - N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by

Guerriero CJ, Weisz OA. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1562-6. Epub 2006 Nov 8.

N-wasp and the arp2/3 complex are critical regulators of actin in the development - N-wasp and the arp2/3 complex are critical regulators of actin in the development

Wegner AM, Nebhan CA, Hu L, Majumdar D, Meier KM, Weaver AM, Webb DJ. J Biol Chem. 2008 Jun 6;283(23):15912-20.