Wortmannin

• Supplier: Tocris Bioscience
• Catalog: 5148
• Prices: $89.00, $345.00
• Sizes: 1 mg, 5 mg
• Function Type: Inhibitor
• Cas Number: 19545-26-7
• Chemical Name: (1S,6bR,9aS,11R,11bR)11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
• Formula: C23H24O8
• Molecular Weight: 428.44
• Description: Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC 50 = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC 50 = 5.8 nM).

Product References

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of - Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of

Arcaro A, Wymann MP. Biochem J. 1993 Dec 1;296 ( Pt 2):297-301.

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. - Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

Powis G, Bonjouklian R, Berggren MM, Gallegos A, Abraham R, Ashendel C, Zalkow L, Matter WF, Dodge J, Grindey G, et al.. Cancer Res. 1994 May 1;54(9):2419-23.

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase - In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase

Schultz RM, Merriman RL, Andis SL, Bonjouklian R, Grindey GB, Rutherford PG, Gallegos A, Massey K, Powis G. Anticancer Res. 1995 Jul-Aug;15(4):1135-9.

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently - Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently

Liu Y, Shreder KR, Gai W, Corral S, Ferris DK, Rosenblum JS. Chem Biol. 2005 Jan;12(1):99-107.